The major goal of this project is to develop an integrated prosthetic control system that involves interviewing limb loss subjects to understand the current needs; the miniaturization of sonomyography sensors and associated electronics to fit within a prosthetic socket; development of control algorithms for commercially available multi-articulated prosthetic hands; studying the long term effects of continuous ultrasound exposure, and finally evaluating the performance of such systems in subjects with upper limb loss against current commercial myoelectric direct control and pattern recognition technology using clinical outcome measures.